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Face Off is an American reality television series. Twelve contestants compete in special effects makeup challenges. Actress McKenzie Westmore, a member of the pioneering Westmore family of makeup artists, serves as host. Judges are multiple Academy Award-winning makeup artist Ve Neill (Ed Wood, Beetlejuice), television makeup artist Glenn Hetrick (Buffy the Vampire Slayer, Babylon and creature designer Patrick Tatopoulos (I Am Legend, Resident Evil: Extinction). Industry figures and artists including Sean S. Cunningham, Filippo Ioco, Greg Nicotero and Michael Westmore will serve as guest judges.

Each week the artists will face two challenges, the "Foundation Challenge" and the "Spotlight Challenge". The Foundation Challenge winner receives an advantage in the Spotlight Challenge. The Face Off winner will receive $100,000, a year's supply of makeup, and a "grand prize that will launch a career".